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Dr Sudarshan Pandit's Blood Plus Hematology Center A blood disorder involving lower-than-normal amounts of an oxygen-carrying protein. Thalassemia is an inherited blood disorder characterised by less oxygen-carrying protein (haemoglobin) and fewer red blood cells in the body than normal. Symptoms include fatigue, weakness, paleness and slow growth. Mild forms may not need treatment. Severe forms may require blood transfusions or a donor stem-cell transplant.